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Unbelievable world inside our gut

Diet and medications are important drivers of human microbiome composition and functional diversity. Medications such as antibiotics have saved billion of lives, but their over prescription has led to several negative effects on gut microbiota, including reduced species diversity, impaired metabolic activity, and selection of antibiotic-resistant organisms.

 

Antibiotic treatment disturbs the microbial balance of gut microbiota. This can have both short and long-term consequences. Indeed, even if short, antibiotic treatment can shift the gut microbiota to long-term alternative dysbiotic state, which may promote the development and/or aggravation of some diseases, like obesity, diabetes, and asthma.

 

Knowledge of the gut microbiome and the impact of antibiotic treatment on our intestinal flora may help practitioners to better understand the importance of taking care of our microbiota, specially thanks to protective role of probiotics, such as Saccharomyces boulardii CNCM I-745.

Unbelievable world inside our gut

Diet and medications are important drivers of human microbiome composition and functional diversity. Medications such as antibiotics have saved billion of lives, but their over prescription has led to several negative effects on gut microbiota, including reduced species diversity, impaired metabolic activity, and selection of antibiotic-resistant organisms.

 

Antibiotic treatment disturbs the microbial balance of gut microbiota. This can have both short and long-term consequences. Indeed, even if short, antibiotic treatment can shift the gut microbiota to long-term alternative dysbiotic state, which may promote the development and/or aggravation of some diseases, like obesity, diabetes, and asthma.

 

Knowledge of the gut microbiome and the impact of antibiotic treatment on our intestinal flora may help practitioners to better understand the importance of taking care of our microbiota, specially thanks to protective role of probiotics, such as Saccharomyces boulardii CNCM I-745.

Program

This TV show focuses on providing key information about the gut microbiome and the antibiotic effect on it. In a dynamic and interactive way, this event is hosted by a scientific journalist, Sue Saville, who interviews Prof. Elena Verdu, an expert on host-microbial and dietary interactions.

 

In a quick video, Dr. Joël Doré develops the gut microbiota structure and composition.

 

Prof. Verdu follows with a focus on the roles of gut microbiota in human health and diseases. She also describes disruption to the balance of gut flora, known as dysbiosis, and the factors that shape the microbiota of the adult intestine, including antibiotics and their role as disruptors of the diversity and richness of gut microflora.

 

To conclude, Dr. Xavier Roux, shows the potential role of Saccharomyces boulardii CNCM I-745 as a natural and effective way to prevent the antibiotic side effects.

About the speakers

Prof. Elena Verdu

MD, PhD, Professor division of gastroenterology, Dept of medicine, McMaster University (Ontario, Canada)

Prof. Elena Verdu is a Professor at Mc Master University, Division of Gastroenterology, and a Canada Research Chair in Inflammation, Microbiota and Nutrition. She is Associate Director of the Farncombe Family Digestive Health Research Institute. The purpose of this Institute is to better understand, treat, and ultimately cure, the most common categories of intestinal illness that burden our society: inflammatory, functional and diet-induced disorders. She is also Director of Axenic Gnotobiotic Unit of the McMaster University. 

Dr. Joël Doré

PhD, Scientific Director of the MetaGenoPolis, Center of Excellence in Microbiome Analysis (Paris, France)

Joël Doré is Research Director at the French National Institute for Research in Agriculture, Food and the Environment INRAE. He is Scientific Director of the center of excellence MetaGenoPolis, a Unit of the Micalis Institute “Food and Gut Microbiology for Human Health” (mixed research unit associated INRAE, AgroParisTech and Université Paris-Saclay).

 

Joël Doré also chairs the expert group of the scientific web-platform www.gutmicrobiotaforhealth.com. Finally, he is scientific advisor for MaaT Pharma (www.maatpharma.com), a startUp developing innovative microbiotherapy solutions designed to restore man-microbes symbiosis in cancer therapy.

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