Prof. Alessio Fasano
Prof. Alessio Fasano is chief of Pediatric Gastroenterology and Nutrition at MassGeneral Hospital for Children (MGHfC). As Director of the Mucosal Immunology and Biology Research Center (MIBRC) at MGHfC, Prof. Fasano explores the host’s immune system and the role of dysbiosis on the onset and progression of celiac disease and other disorders in order to develop preventive strategies.
- Professor of Pediatrics, Harvard Medical School, Boston, MA, USA
- Professor of Nutrition, Harvard T.H Chan School of Public Health, Boston, MA, USA
- W. Allan Walker Chair of Pediatric Gastroenterology and Nutrition at MassGeneral Hospital for Children, Boston, MA, USA
- Chief of the Division of Pediatric Gastroenterology and Nutrition at MassGeneral Hospital for Children, Boston, MA, USA
- Director of the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children, Boston, MA, USA
- Associate Chief for Basic, Clinical and Translational Research at MassGeneral Hospital for Children, Boston, MA, USA
- Founder and Director of the Center for Celiac Research and Treatment at Massachusetts General Hospital, Boston, MA, USA
- Director of the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children, Boston, MA, USA
Prof. Alessio Fasano is chief of Pediatric Gastroenterology and Nutrition at MassGeneral Hospital for Children (MGHfC). As Director of the Mucosal Immunology and Biology Research Center (MIBRC) at MGHfC, Prof. Fasano explores the host’s immune system and the role of dysbiosis on the onset and progression of celiac disease and other disorders in order to develop preventive strategies.
- Professor of Pediatrics, Harvard Medical School, Boston, MA, USA
- Professor of Nutrition, Harvard T.H Chan School of Public Health, Boston, MA, USA
- W. Allan Walker Chair of Pediatric Gastroenterology and Nutrition at MassGeneral Hospital for Children, Boston, MA, USA
- Chief of the Division of Pediatric Gastroenterology and Nutrition at MassGeneral Hospital for Children, Boston, MA, USA
- Director of the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children, Boston, MA, USA
- Associate Chief for Basic, Clinical and Translational Research at MassGeneral Hospital for Children, Boston, MA, USA
- Founder and Director of the Center for Celiac Research and Treatment at Massachusetts General Hospital, Boston, MA, USA
- Director of the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children, Boston, MA, USA
As a world-renowned pediatric gastroenterologist, research scientist and passionate advocate for collaboration in research and clinical work, his research projects embrace the basic science of the gut microbiome and intestinal biology, and the translational science, with interventional clinical trials in autoimmune and inflammatory diseases. His discovery of zonulin in 2000, a regulator of intestinal permeability, eventually led to his development of a complementary therapeutic, larazotide acetate, which is now in Phase 3 trials for celiac disease. Prof. Fasano and team members at MGHfC more recently received emergency, compassionate use to successfully treat severely ill children suffering from COVID-19 complications with larazotide acetate, and clinical trials are underway to treat children with MIS-C.
Besides being widely sought after as an expert in celiac disease, intestinal permeability and autoimmune disorders, Prof. Fasano has authored several evidence-based and entertaining books to provide patients, healthcare providers and lay public readers information about gluten and its role in health and the role of the microbiome and human health.
His visionary research and the impact of his more than 425 peer-reviewed journal publications and his 160 patents make him recognized as one of the world's most highly cited researchers in the 2020 Web of Science Group Report.
Fasano Lab (https://www.massgeneral.org/children/mucosal-immunology/faculty/fasano-lab)
Center for Celiac Research and Treatment (https://www.massgeneral.org/children/celiac-disease)
Harvard Medical School Celiac Research Program (https://hms.harvard.edu/departments/hms-celiac-research-program)
Beopoulos A. et al.
Autonomic Nervous System Neuroanatomical Alterations Could Provoke and Maintain Gastrointestinal Dysbiosis in Autism Spectrum Disorder (ASD): A Novel Microbiome-Host Interaction Mechanistic Hypothesis
Nutrients. 2021 Dec 24;14(1):65.
Leonard MM. et al.
Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study
Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2020322118.
Shah NB. et al.
The Gut and Blood Microbiome in IgA Nephropathy and Healthy Controls
Kidney360. 2021 Jun 9;2(8):1261-1274.
Monteleone AM. et al.
Multi-omics data integration in anorexia nervosa patients before and after weight regain: A microbiome-metabolomics investigation
Clin Nutr. 2021 Mar;40(3):1137-1146.
Monteleone AM. et al.
The Gut Microbiome and Metabolomics Profiles of Restricting and Binge-Purging Type Anorexia Nervosa
Nutrients. 2021 Feb 4;13(2):507.
Olshan KL. et al.
Gut microbiota in Celiac Disease: microbes, metabolites, pathways and therapeutics
Expert Rev Clin Immunol. 2020 Nov;16(11):1075-1092.
Leonard MM. et al.
Multi-omics analysis reveals the influence of genetic and environmental risk factors on developing gut microbiota in infants at risk of celiac disease
Microbiome. 2020 Sep 11;8(1):130.
Fasano A.
Another reason to favor exclusive breastfeeding: microbiome resilience
J Pediatr (Rio J). May-Jun 2018;94(3):224-225.
Prof. Alessio Fasano’s Microbiota Events
Scientific advances from ESPGHAN 2022
